Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PDE8B | O95263 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22164278 | 1.00 | TSHR (0.34) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL22176306 | 0.86 | KLK7 (0.41) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL30311378 | 0.86 | KLK7 (0.41) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL2737942 | 0.85 | PDE8B (0.40) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL22175827 | 0.84 | PDE8B (0.37) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL22164263 | 0.84 | PDE8B (0.37) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL22164195 | 0.81 | TSHR (0.40) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL221557 | 0.80 | TSHR (0.38) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL21279510 | 0.77 | TSHR (0.37) | TSHRLMNAMEN1KMT2AMAPT | |
| SCHEMBL2737893 | 0.77 | TSHR (0.37) | TSHRLMNAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |