Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL1587834 | 1.00 | — | — | |
| Nitric Acid SCHEMBL2217977 | 1.00 | CA5A (0.67) | CA5ACA5BTSHRALDH1A1TDP1 | |
| Butane SCHEMBL7161573 | 0.88 | CA5A (0.61) | CA5ACA5BTSHRALDH1A1TDP1 | |
| Nitric Acid SCHEMBL8124021 | 0.88 | CA5A (0.61) | CA5ACA5BTSHRALDH1A1TDP1 | |
| Nitric Acid SCHEMBL420115 | 0.88 | — | — | |
| Butane SCHEMBL18261807 | 0.88 | — | — | |
| Nitric Acid SCHEMBL7266184 | 0.85 | CA5A (0.57) | CA5ACA5BTSHRALDH1A1TDP1 | |
| Butane SCHEMBL11144889 | 0.85 | — | — | |
| Nitric Acid SCHEMBL6705592 | 0.85 | — | — | |
| Nitric Acid SCHEMBL5863983 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110177964-A1 | CHEMOSENSORY ARRAYS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2011-07-21 | — | — | US | disclosed |
| CN-101050156-A | New type bottom drainage drug | UNIV SHENYANG PHARMACY (CN) | 2007-10-10 | — | — | CN | disclosed |
| US-6610977-B2 | Security system for NBC-safe building | LOCKHEED MARTIN CORPORATION | 2003-08-26 | — | — | US | disclosed |
| US-4111728-A | POLYETHER OF POLYESTER BINDER, MAGNESIUM OXIDE OR NITRATE COATED AMMONIUM NITRATE | RAMNARACE JAWAHARLAL | 1978-09-05 | — | — | US | disclosed |