Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12444667 | 1.00 | RAF1 (0.34) | RAF1CYP2E1CHEK1CHEK2RAB9A | |
| SCHEMBL12444669 | 1.00 | RAF1 (0.34) | RAF1CYP2E1CHEK1CHEK2RAB9A | |
| SCHEMBL14669356 | 0.92 | CYP2E1 (0.32) | RAF1CYP2E1RAB9ASMN1; SMN2NR1I2 | |
| SCHEMBL669322 | 0.90 | ALDH1A1 (0.33) | RAF1CYP2E1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL669880 | 0.89 | RAF1 (0.36) | RAF1CYP2E1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1963295 | 0.86 | CYP2E1 (0.39) | RAF1CYP2E1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL1960225 | 0.85 | RAF1 (0.34) | RAF1KDM4EHTTATMNR1I2 | |
| SCHEMBL1960222 | 0.85 | RAF1 (0.34) | RAF1KDM4EHTTATMNR1I2 | |
| SCHEMBL669498 | 0.84 | NR1I2 (0.34) | RAF1CYP2E1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL102080 | 0.83 | CHEK1 (0.42) | RAF1CYP2E1CHEK1CHEK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3219713-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2523950-B1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2017-03-15 | — | — | EP | disclosed |
| US-9321753-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2016-04-26 | — | — | US | disclosed |
| US-20130315861-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. | 2013-11-28 | — | — | US | disclosed |
| US-8513298-B2 | Inhibitors of flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2523950-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | Gilead Sciences, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| US-20110178129-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| WO-2011088345-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130315861-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | RAF1 1470/4885CYP2E1 6/4885CHEK1 4164/4885 |
| US-20110178129-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | RAF1 1470/4885CYP2E1 6/4885CHEK1 4164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.