Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22199040 | 0.82 | MAOA (0.52) | MAOAMAOBCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL22185841 | 0.77 | MAOA (0.38) | MAOAMAOBPTGS2CYP3A4PSEN1 | |
| SCHEMBL4427652 | 0.76 | PDE3B (0.40) | MAOAMAOBPTGS2CYP2C9CYP1A2 | |
| SCHEMBL4433503 | 0.72 | NOTUM (0.43) | PTGS2CYP2C9CYP1A2CYP2C19NOTUM | |
| SCHEMBL4428160 | 0.72 | PDE3B (0.39) | MAOAMAOBPTGS2PSEN1PSEN2 | |
| SCHEMBL10233672 | 0.72 | CYP3A4 (0.38) | MAOACYP2C9CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8815608 | 0.70 | NR4A1 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL22185880 | 0.70 | MAP4K4 (0.42) | CYP2C9CYP1A2CYP3A4CYP2D6CYP19A1 | |
| SCHEMBL18101813 | 0.70 | CYP11B1 (0.59) | MAOAMAOBCYP2C9CYP1A2CYP3A4 | |
| SCHEMBL4427890 | 0.70 | NOTUM (0.55) | CYP2C9CYP1A2CYP3A4CYP2D6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2020-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200206233-A1 | HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS | IDH1, IDH2, IDH3A | MAOA 1461/4885MAOB 1259/4885PTGS2 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.