Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK1 | P23458 | 2/20 | 0.53 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.52 |
| ▸ | GSK3B | P49841 | 7/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19558436 | 0.94 | ACVRL1 (0.58) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL15358580 | 0.85 | TYK2 (0.50) | TYK2JAK2JAK1ACVRL1GSK3B | |
| Hydrochloric Acid SCHEMBL15350753 | 0.83 | TYK2 (0.49) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL15358584 | 0.82 | TYK2 (0.50) | TYK2JAK2JAK1ACVRL1GSK3B | |
| Hydrochloric Acid SCHEMBL15350150 | 0.81 | TYK2 (0.49) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL10199545 | 0.81 | BRAF (0.61) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL23893005 | 0.79 | ABL1 (0.56) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL26686286 | 0.79 | TYK2 (0.59) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL16914215 | 0.79 | TYK2 (0.62) | TYK2JAK2JAK1ACVRL1GSK3B | |
| SCHEMBL15358565 | 0.78 | ACVRL1 (0.55) | TYK2ACVRL1GSK3BMAPTPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020138271-A1 | HETEROCYCLIC DERIVATIVES AS Nav1.7 and Nav1.8 BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2020-07-02 | — | — | WO | disclosed |