Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27333271 | 0.90 | NPC1 (0.44) | MAPTNPC1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL15617823 | 0.88 | NPC1 (0.43) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL22190232 | 0.85 | MEN1 (0.41) | APPNPC1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL29469520 | 0.85 | MEN1 (0.41) | APPNPC1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL4190714 | 0.84 | KDM4E (0.50) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL28074874 | 0.81 | NPC1 (0.42) | MAPTNPC1ALDH1A1CYP2D6CYP2C19 | |
| SCHEMBL15911434 | 0.80 | NPC1 (0.43) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL10403787 | 0.79 | NPC1 (0.40) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL10403788 | 0.79 | NPC1 (0.40) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E | |
| SCHEMBL14884315 | 0.79 | NCF1 (0.42) | NPC1ALDH1A1CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020140924-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | 原子高科股份有限公司 | 2020-07-09 | — | — | WO | disclosed |