Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.49 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21295271 | 0.77 | CYP1A2 (0.50) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL2192514 | 0.75 | NAMPT (0.55) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL13256589 | 0.72 | CDK2 (0.60) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL9684691 | 0.68 | KDM4E (0.65) | KDM4EALDH1A1HPGDGLO1AR | |
| SCHEMBL1998243 | 0.67 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL6365958 | 0.67 | KDM4E (0.54) | KDM4EALDH1A1HPGDCYP19A1GLO1 | |
| SCHEMBL1998246 | 0.67 | ALDH1A1 (0.37) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL22533985 | 0.67 | CDK2 (0.49) | HPGDKMT2AMEN1HTT | |
| SCHEMBL29424829 | 0.67 | CDK2 (0.49) | HPGDKMT2AMEN1HTT | |
| SCHEMBL2188602 | 0.67 | CTSA (0.48) | HPGDKMT2AMEN1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | ARQULE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172203-A1 | Substituted Imidazopyridinyl-Aminopyridine Compounds | MKI67, CDK4, ABL1 | KDM4E 933/4885ALDH1A1 651/4885HPGD 457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.