Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | FER | P16591 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | MARK3 | P27448 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.50 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28644765 | 0.95 | PLK4 (0.55) | PLK4CHEK1PRKD3MAP4K4CDK1 | |
| SCHEMBL22191488 | 0.90 | KDM4E (0.47) | PLK4CHEK1PRKD3MAP4K4CDK1 | |
| SCHEMBL22191347 | 0.88 | PDE3B (0.60) | PLK4CHEK1PRKD3MAP4K4CDK1 | |
| SCHEMBL22191489 | 0.88 | HPGD (0.50) | PLK4CHEK1PRKD3MAP4K4CDK1 | |
| SCHEMBL22190941 | 0.87 | HDAC1 (0.49) | CDK2CLK4PDE3BPDE3AVNN1 | |
| SCHEMBL22191321 | 0.87 | DYRK1A (0.48) | MAP4K4PIM1CDK2GSK3BCLK4 | |
| SCHEMBL22191481 | 0.87 | VNN1 (0.48) | PDE3BPDE3AVNN1HDAC3HDAC1 | |
| SCHEMBL22190998 | 0.87 | GAA (0.47) | PDE3BPDE3AVNN1DYRK1AKMT2A | |
| SCHEMBL22191334 | 0.87 | PLK4 (0.48) | PLK4CHEK1PRKD3MAP4K4CDK1 | |
| SCHEMBL22191518 | 0.86 | PDE3B (0.45) | PLK4CHEK1PRKD3MAP4K4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3906028-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | Icahn School of Medicine at Mount Sinai (US) | 2021-11-10 | — | — | EP | disclosed |
| CN-113543783-A | Kinase inhibitor compounds and compositions and methods of use | 西奈山伊坎医学院 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020142486-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-07-09 | — | — | WO | disclosed |