Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437806 | 1.00 | DYRK1A (0.48) | DYRK1APIK3CBPIK3CACYP3A4CYP2C9 | |
| SCHEMBL22191387 | 0.89 | MAPT (0.54) | DYRK1APIK3CBPIK3CACYP3A4CYP2C9 | |
| SCHEMBL22190920 | 0.84 | GAA (0.64) | DYRK1ACYP2C9MAPTGAAMEN1 | |
| SCHEMBL22190817 | 0.84 | GAA (0.54) | DYRK1AHDAC3MAPTGAAMEN1 | |
| SCHEMBL22191663 | 0.84 | GAA (0.46) | DYRK1APIK3CBPIK3CACYP3A4CYP2C9 | |
| SCHEMBL22191275 | 0.83 | GAA (0.48) | DYRK1APIK3CBPIK3CACYP3A4CYP2C9 | |
| SCHEMBL22191095 | 0.82 | PLK4 (0.50) | DYRK1AHDAC3MAPTGAAKMT2A | |
| SCHEMBL22191518 | 0.81 | PDE3B (0.45) | GAAMEN1KMT2APLK4CHEK1 | |
| SCHEMBL29664534 | 0.81 | PIK3CB (0.46) | DYRK1APIK3CBPIK3CACYP3A4CYP2C9 | |
| SCHEMBL29437817 | 0.80 | MKNK2 (0.44) | DYRK1AHDAC3MAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3906028-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | Icahn School of Medicine at Mount Sinai (US) | 2021-11-10 | — | — | EP | disclosed |
| CN-113543783-A | Kinase inhibitor compounds and compositions and methods of use | 西奈山伊坎医学院 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020142486-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-07-09 | — | — | WO | disclosed |