Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MC5R | P33032 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29437825 | 1.00 | PIK3CB (0.46) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL22191387 | 0.84 | MAPT (0.54) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL22191275 | 0.82 | GAA (0.48) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL29437806 | 0.79 | DYRK1A (0.48) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL22191264 | 0.79 | DYRK1A (0.48) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL22191663 | 0.77 | GAA (0.46) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL22191096 | 0.77 | PSEN1 (0.52) | DYRK1AMAPTMEN1KMT2ALMNA | |
| SCHEMBL12287060 | 0.76 | DYRK1A (0.35) | DYRK1AMAPTGAAPDE3BPDE3A | |
| SCHEMBL29664534 | 0.76 | PIK3CB (0.46) | PIK3CBPIK3CACYP3A4CYP2C9DYRK1A | |
| SCHEMBL12289961 | 0.75 | PDE3B (0.41) | MAPTPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3906028-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | Icahn School of Medicine at Mount Sinai (US) | 2021-11-10 | — | — | EP | disclosed |
| CN-113543783-A | Kinase inhibitor compounds and compositions and methods of use | 西奈山伊坎医学院 | 2021-10-22 | — | — | CN | disclosed |
| WO-2020142486-A1 | KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2020-07-09 | — | — | WO | disclosed |