Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | JAK2 | O60674 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 13/20 | 0.62 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1718112 | 0.85 | ALDH1A1 (0.73) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL3069160 | 0.78 | EPHX2 (1.00) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL3076325 | 0.76 | EPHX2 (0.69) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL9743900 | 0.74 | HDAC3 (0.64) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL11573469 | 0.72 | EPHX2 (0.71) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL16492446 | 0.71 | EPHX2 (0.74) | EPHX2EPHX1HTTMEN1KMT2A | |
| SCHEMBL14503292 | 0.71 | EPHX2 (0.77) | EPHX2HTTMEN1KMT2A | |
| SCHEMBL24667562 | 0.71 | ALDH1A1 (0.55) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL19808524 | 0.71 | ALDH1A1 (0.55) | LMNAJAK2ALDH1A1RAB9AEPHX2 | |
| SCHEMBL13923630 | 0.71 | EPHX2 (0.75) | LMNAJAK2ALDH1A1RAB9AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220298213-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | VIVIDION THERAPEUTICS, INC. | 2022-09-22 | — | — | US | disclosed |
| US-20210002337-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | THE SCRIPPS RESEARCH INSTITUTE | 2021-01-07 | — | — | US | disclosed |
| US-20200216507-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | VIVIDION THERAPEUTICS, INC. | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220298213-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | CRBN, CDR2, DCUN1D4 | LMNA 1798/4885JAK2 4133/4885ALDH1A1 2798/4885 |
| US-20200216507-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | CRBN, CDR2, DCUN1D4 | LMNA 1798/4885JAK2 4133/4885ALDH1A1 2798/4885 |
| US-20210002337-A1 | IN VIVO ENGINEERED CEREBLON PROTEIN | CRBN, CDR2, DCUN1D4 | LMNA 1798/4885JAK2 4133/4885ALDH1A1 2798/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.