Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.64 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.46 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6276798 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL627424 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL1078114 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL6278204 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL627474 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL6272996 | 1.00 | PAOX (0.64) | PAOXMAOAMAOBGNAI3GNAO1 | |
| SCHEMBL1332569 | 0.97 | — | — | |
| SCHEMBL3406422 | 0.90 | — | — | |
| SCHEMBL1309360 | 0.89 | KDM4E (0.52) | PAOXKDM4EMAPK1HIF1AALDH1A1 | |
| SCHEMBL1837168 | 0.89 | KDM4E (0.52) | PAOXKDM4EMAPK1HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |