Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.59 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.59 |
| ▸ | FURIN | P09958 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22198241 | 0.98 | TRIM24 (0.61) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL22198292 | 0.84 | CA12 (0.49) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL22198146 | 0.84 | SLC2A1 (0.59) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL13855689 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL13855691 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL11226301 | 0.82 | TRIM24 (0.57) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL20014003 | 0.82 | TRIM24 (0.57) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL11226294 | 0.82 | TRIM24 (0.57) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 | |
| SCHEMBL22198154 | 0.82 | ALDH1A1 (0.67) | ALDH1A1KDM4ESMN1; SMN2FURINMAPT | |
| SCHEMBL7718270 | 0.80 | ALDH1A1 (0.69) | ALDH1A1KDM4ESMN1; SMN2TRIM24TRIM33 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393810-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO A BETA PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | HTA Co., Ltd. (CN) | 2021-12-23 | — | — | US | disclosed |
| WO-2020140924-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO AΒ PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | 原子高科股份有限公司 | 2020-07-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393810-A1 | DIHYDRAZONE COMPOUNDS HAVING HIGH AFFINITY TO A BETA PROTEIN AND TAU PROTEIN, DERIVATIVES THEREOF AND USE THEREOF | MAPT, APP, PSEN1 | ALDH1A1 1343/4885KDM4E 4710/4885SMN1; SMN2 2538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.