Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 10/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29355989 | 0.88 | ERN1 (0.54) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22190707 | 0.88 | ERN1 (0.54) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22191839 | 0.88 | ERN1 (0.54) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL29352852 | 0.88 | ERN1 (0.54) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22200443 | 0.86 | ERN1 (0.45) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22200592 | 0.83 | ERN1 (0.55) | ERN1MAPK8MAPK10MAPK9CCNT1 | |
| SCHEMBL22200533 | 0.81 | ERN1 (0.42) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL25035479 | 0.81 | ERN1 (0.51) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22200305 | 0.81 | ERN1 (0.51) | ERN1MAPK8MAPK10MAPK9BRAF | |
| SCHEMBL22191051 | 0.81 | ERN1 (0.51) | ERN1MAPK8MAPK10MAPK9BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |