Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCND2 | P30279 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | WEE1 | P30291 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | GAK | O14976 | 1/20 | 0.31 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190769 | 0.84 | ERN1 (0.51) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL22200333 | 0.84 | ERN1 (0.46) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL29355774 | 0.84 | ERN1 (0.51) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL22200443 | 0.83 | ERN1 (0.45) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL22200324 | 0.82 | ERN1 (0.40) | ERN1FGFR1BRAFBTKFGFR2 | |
| SCHEMBL22200341 | 0.81 | ERN1 (0.46) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL22200537 | 0.76 | BRAF (0.37) | ERN1FGFR1BRAFBTKFGFR2 | |
| SCHEMBL22190679 | 0.75 | ERN1 (0.60) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL29356440 | 0.75 | ERN1 (0.60) | ERN1FGFR1MAPK8MAPK14CDK4 | |
| SCHEMBL25035286 | 0.72 | ERN1 (0.47) | ERN1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |