Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.42 |
| ▸ | BTK | Q06187 | 3/20 | 0.35 |
| ▸ | WEE1 | P30291 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | SIK1 | P57059 | 1/20 | 0.32 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.32 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCND2 | P30279 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 2/20 | 0.30 |
| ▸ | LYN | P07948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200564 | 0.91 | ERN1 (0.39) | ERN1BTKWEE1ABL1MAPT | |
| SCHEMBL22200701 | 0.90 | ERN1 (0.42) | ERN1BTKWEE1ABL1FGFR1 | |
| SCHEMBL22200333 | 0.88 | ERN1 (0.46) | ERN1BTKWEE1ABL1FGFR1 | |
| SCHEMBL22200335 | 0.81 | WEE1 (0.34) | ERN1WEE1ABL1FGFR1MAPT | |
| SCHEMBL22200561 | 0.81 | ERN1 (0.39) | ERN1BTKWEE1ABL1FGFR1 | |
| SCHEMBL22200534 | 0.80 | ERN1 (0.39) | ERN1FGFR1BRAFSRC | |
| SCHEMBL22190811 | 0.79 | ERN1 (0.50) | ERN1BTKWEE1ABL1BRAF | |
| SCHEMBL29356779 | 0.79 | ERN1 (0.50) | ERN1BTKWEE1ABL1BRAF | |
| SCHEMBL22200371 | 0.79 | PIK3CA (0.38) | BTKABL1FGFR1BRAFSRC | |
| SCHEMBL22191061 | 0.78 | ERN1 (0.35) | ERN1BTKABL1SIK1SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |