Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.33 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PKLR | P30613 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200519 | 0.91 | ERN1 (0.42) | ERN1BTKABL1SRCWEE1 | |
| SCHEMBL22200561 | 0.90 | ERN1 (0.39) | ERN1TSHRHTTBTKABL1 | |
| SCHEMBL22190811 | 0.85 | ERN1 (0.50) | ERN1TSHRHTTBTKABL1 | |
| SCHEMBL29356779 | 0.85 | ERN1 (0.50) | ERN1TSHRHTTBTKABL1 | |
| SCHEMBL22200566 | 0.83 | ERN1 (0.40) | ERN1TSHRHTTBTKABL1 | |
| SCHEMBL22200701 | 0.81 | ERN1 (0.42) | ERN1BTKABL1SRCWEE1 | |
| SCHEMBL22200333 | 0.79 | ERN1 (0.46) | ERN1BTKABL1WEE1MAPK14 | |
| SCHEMBL22200391 | 0.78 | ERN1 (0.35) | ERN1TSHRHTTBTKABL1 | |
| SCHEMBL22191061 | 0.77 | ERN1 (0.35) | ERN1BTKABL1 | |
| SCHEMBL29353184 | 0.77 | ERN1 (0.35) | ERN1BTKABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |