Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3079738 | 0.77 | KMT2A (0.43) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL29386373 | 0.77 | KMT2A (0.43) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL10817318 | 0.76 | AMY1A (0.42) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL22200728 | 0.74 | HPGD (0.37) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL3772270 | 0.74 | HTR2A (0.41) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL4547157 | 0.74 | MAPT (0.41) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL30558293 | 0.74 | HTR2A (0.41) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL14327980 | 0.72 | IDO1 (0.41) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL21032335 | 0.72 | CYP1A2 (0.41) | L3MBTL1MAPTTDP1HPGDNPC1 | |
| SCHEMBL1588133 | 0.72 | NPC1 (0.38) | L3MBTL1MAPTTDP1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |