Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.38 |
| ▸ | MTOR | P42345 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
| ▸ | LYN | P07948 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200585 | 0.90 | BTK (0.40) | BTKPIK3CAMTORSRCEGFR | |
| SCHEMBL22200785 | 0.90 | FGFR1 (0.45) | PIK3CAMTORSRCEGFRFGFR1 | |
| SCHEMBL22200653 | 0.86 | MTOR (0.38) | BTKPIK3CAMTOR | |
| SCHEMBL22200738 | 0.86 | BTK (0.40) | BTKPIK3CAMTORSRCEGFR | |
| SCHEMBL25035531 | 0.82 | FEN1 (0.40) | BTKPIK3CAMTORBRAF | |
| SCHEMBL25035471 | 0.78 | BTK (0.40) | BTKPIK3CAMTORBRAF | |
| SCHEMBL22200424 | 0.77 | MTOR (0.37) | PIK3CAMTORSRCEGFRFGFR1 | |
| SCHEMBL22200363 | 0.77 | EGFR (0.46) | BTKPIK3CAMTORSRCEGFR | |
| SCHEMBL25035635 | 0.76 | BTK (0.38) | BTKPIK3CAMTORSRCEGFR | |
| SCHEMBL25035541 | 0.75 | EGFR (0.42) | PIK3CAMTORSRCEGFRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |