Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 9/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200424 | 0.91 | MTOR (0.37) | MTORPIK3CARORC | |
| SCHEMBL22200818 | 0.88 | MTOR (0.36) | MTORPIK3CARORC | |
| SCHEMBL22200739 | 0.86 | BTK (0.43) | MTORBTKPIK3CA | |
| SCHEMBL25034228 | 0.82 | FEN1 (0.39) | MTORPIK3CARORCALOX5APFEN1 | |
| SCHEMBL22200825 | 0.81 | CYP1A2 (0.36) | MTORBTKRORCALDH1A1HPGD | |
| SCHEMBL22200792 | 0.80 | MTOR (0.35) | MTORPIK3CARORC | |
| SCHEMBL22200378 | 0.78 | ERN1 (0.34) | ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL22200802 | 0.77 | MTOR (0.41) | MTORPIK3CAALDH1A1HPGDHSD17B10 | |
| SCHEMBL25035336 | 0.76 | PKM (0.41) | MTORPIK3CARORCALOX5APFEN1 | |
| SCHEMBL25035392 | 0.76 | ERN1 (0.41) | MTORRORCALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |