Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 5/20 | 0.33 |
| ▸ | ERN1 | O75460 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200594 | 0.94 | RORC (0.34) | RORCERN1BRAF | |
| SCHEMBL22200826 | 0.89 | ERN1 (0.39) | RORCMTORERN1PIK3CARPS6KA3 | |
| SCHEMBL25035364 | 0.85 | ERN1 (0.42) | RORCMTORERN1PIK3CABRAF | |
| SCHEMBL22200788 | 0.83 | USP2 (0.40) | ERN1 | |
| SCHEMBL22200612 | 0.82 | RORC (0.35) | RORCERN1BRAF | |
| SCHEMBL25035534 | 0.82 | RORC (0.39) | RORC | |
| SCHEMBL22200635 | 0.82 | ERN1 (0.39) | ERN1 | |
| SCHEMBL22200816 | 0.81 | ERN1 (0.38) | RORCMTORERN1 | |
| SCHEMBL22200549 | 0.81 | ERN1 (0.37) | MTORERN1 | |
| SCHEMBL22200721 | 0.79 | RORC (0.35) | RORCMTORERN1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142612-A1 | PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES. | GENENTECH, INC. (US) | 2020-07-09 | — | — | WO | disclosed |