Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 13/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.53 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | BLK | P51451 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | STK3 | Q13188 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.47 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201300 | 0.92 | TGFBR1 (0.52) | TGFBR1ROCK2ROCK1PKN2PDE5A | |
| SCHEMBL3587471 | 0.86 | PDE5A (0.65) | TGFBR1ROCK2ROCK1EGFRFLT1 | |
| SCHEMBL22201251 | 0.86 | MKNK1 (0.47) | TGFBR1ROCK2ROCK1EGFRFLT1 | |
| SCHEMBL22201263 | 0.85 | TGFBR1 (0.61) | TGFBR1CSNK2A1EGFRFLT1PDE5A | |
| SCHEMBL3587569 | 0.84 | TGFBR1 (0.69) | TGFBR1ROCK2ROCK1CLK2BLK | |
| SCHEMBL13154697 | 0.83 | TGFBR1 (0.71) | TGFBR1ROCK2ROCK1CLK2BLK | |
| SCHEMBL29395013 | 0.83 | TGFBR1 (0.71) | TGFBR1ROCK2ROCK1CLK2BLK | |
| SCHEMBL3584767 | 0.82 | KDM1A (0.62) | TGFBR1ROCK2ROCK1PAK4CLK2 | |
| SCHEMBL22201253 | 0.82 | PDE5A (0.47) | TGFBR1PDE5AABCG2 | |
| SCHEMBL3578585 | 0.81 | TGFBR1 (0.65) | TGFBR1ROCK2ROCK1CLK2BLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |