Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3311502 | 0.81 | MDM2 (0.66) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13361530 | 0.78 | MAPT (0.62) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3308047 | 0.76 | MDM2 (0.63) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL13361539 | 0.72 | MDM2 (0.59) | MAPTMEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL14478918 | 0.70 | MEN1 (0.79) | MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5331602 | 0.68 | PGR (0.46) | MAPTKMT2ASMN1; SMN2TP53RXFP1 | |
| SCHEMBL22693619 | 0.68 | S1PR2 (0.85) | MAPTRXFP1MDM2 | |
| SCHEMBL22686991 | 0.67 | S1PR2 (0.84) | MAPTTP53RXFP1 | |
| SCHEMBL30485670 | 0.67 | PGR (0.68) | KMT2AMAPK1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL6362477 | 0.67 | PGR (0.68) | KMT2AMAPK1SMN1; SMN2KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |