Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 15/20 | 1.00 |
| ▸ | HPGD | P15428 | 3/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | USP2 | O75604 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CASP1 | P29466 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | TSHR | P16473 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | GSK3A | P49840 | 1/20 | 0.71 |
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | PDE5A | O76074 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1063549 | 0.93 | ABCG2 (1.00) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL14475900 | 0.88 | ABCG2 (0.78) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL7434986 | 0.84 | ALDH1A1 (1.00) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL1083761 | 0.83 | HPGD (1.00) | ABCG2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL14475898 | 0.82 | ABCG2 (0.78) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL22201579 | 0.82 | ABCG2 (0.85) | ABCG2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL1083768 | 0.82 | KDM4E (1.00) | ABCG2HPGDALDH1A1KDM4ELMNA | |
| SCHEMBL3460305 | 0.81 | ALDH1A1 (0.94) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL14262837 | 0.81 | KDM4E (0.94) | ABCG2HPGDCYP1A2USP2CYP3A4 | |
| SCHEMBL7280956 | 0.80 | ABCG2 (1.00) | ABCG2HPGDALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |