Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | PDE5A | O76074 | 8/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.76 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.76 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.76 |
| ▸ | GBA1 | P04062 | 8/20 | 0.75 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | JAK2 | O60674 | 1/20 | 0.67 |
| ▸ | METAP1 | P53582 | 1/20 | 0.67 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | APP | P05067 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1085431 | 0.92 | PDE5A (1.00) | KDM4EMAPK1PDE5AGBA1SLC6A3 | |
| SCHEMBL7277479 | 0.86 | PDE5A (1.00) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL7278036 | 0.86 | GBA1 (1.00) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL4868215 | 0.85 | PDE5A (0.82) | KDM4EMAPK1PDE5AGBA1SLC6A3 | |
| SCHEMBL3459468 | 0.85 | MAPK1 (0.82) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL6698790 | 0.85 | LATS1 (0.76) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL22201478 | 0.85 | GBA1 (0.77) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL22620817 | 0.84 | KDM4E (0.72) | KDM4EMAPK1PDE5APTGS1TBXAS1 | |
| SCHEMBL5138849 | 0.83 | PDE5A (0.82) | KDM4EMAPK1PDE5AGBA1SLC6A3 | |
| SCHEMBL4867362 | 0.83 | PDE5A (0.82) | KDM4EMAPK1PDE5AGBA1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |