Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 19/20 | 0.57 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201791 | 0.88 | IDH1 (0.49) | IDH1DNMT3A | |
| SCHEMBL22201790 | 0.88 | IDH1 (0.63) | IDH1 | |
| SCHEMBL28656739 | 0.85 | IDH1 (0.78) | IDH1 | |
| SCHEMBL19700940 | 0.85 | IDH1 (0.78) | IDH1 | |
| SCHEMBL28656740 | 0.85 | IDH1 (0.78) | IDH1 | |
| SCHEMBL19700762 | 0.85 | IDH1 (0.78) | IDH1 | |
| SCHEMBL19700764 | 0.84 | IDH1 (0.80) | IDH1 | |
| SCHEMBL19701038 | 0.83 | IDH1 (0.63) | IDH1 | |
| SCHEMBL19700697 | 0.81 | DNMT3A (0.54) | DNMT3A | |
| SCHEMBL22201829 | 0.81 | IDH1 (0.83) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-B1 | MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2020-07-08 | — | — | EP | disclosed |