Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.58 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19700709 | 0.89 | IDH1 (0.46) | IDH1HRH4 | |
| SCHEMBL19700777 | 0.88 | IDH1 (0.75) | IDH1 | |
| SCHEMBL21378380 | 0.88 | IDH1 (0.75) | IDH1 | |
| SCHEMBL22201753 | 0.85 | IDH1 (0.81) | IDH1 | |
| SCHEMBL22201787 | 0.83 | IDH1 (0.61) | IDH1 | |
| SCHEMBL19700706 | 0.82 | IDH1 (0.54) | IDH1HRH4 | |
| SCHEMBL22201750 | 0.80 | IDH1 (0.52) | IDH1 | |
| SCHEMBL19191699 | 0.77 | IDH1 (0.59) | IDH1HRH4 | |
| SCHEMBL21399745 | 0.76 | IDH1 (0.70) | IDH1 | |
| SCHEMBL21378556 | 0.76 | IDH1 (0.83) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-B1 | MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2020-07-08 | — | — | EP | disclosed |