Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 18/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19191699 | 0.86 | IDH1 (0.59) | IDH1MKNK1MKNK2OGA | |
| SCHEMBL19700706 | 0.81 | IDH1 (0.54) | IDH1 | |
| SCHEMBL19191680 | 0.81 | IDH1 (0.58) | IDH1MKNK1MKNK2OGA | |
| SCHEMBL22201749 | 0.80 | IDH1 (0.58) | IDH1 | |
| SCHEMBL22604190 | 0.77 | IDH1 (0.52) | IDH1MKNK1MKNK2OGA | |
| SCHEMBL19701256 | 0.76 | IDH1 (0.57) | IDH1 | |
| SCHEMBL22201753 | 0.76 | IDH1 (0.81) | IDH1 | |
| SCHEMBL19700736 | 0.76 | ACHE (0.47) | IDH1 | |
| SCHEMBL19191723 | 0.74 | IDH1 (0.67) | IDH1 | |
| SCHEMBL19191933 | 0.74 | IDH1 (0.55) | IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464281-B1 | MUTANT IDH1 INHIBITORS | LILLY CO ELI (US) | 2020-07-08 | — | — | EP | disclosed |