Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CCL2 | P13500 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2264667 | 0.75 | POLB (0.41) | KDRFGFR3ALKBH1FGFR2FGFR4 | |
| SCHEMBL13274645 | 0.70 | NPC1 (0.33) | KDRFGFR3ALKBH1FGFR2FGFR4 | |
| SCHEMBL13449435 | 0.70 | POLB (0.40) | KDRFGFR3ALKBH1ALDH1A1RXRA | |
| SCHEMBL2271726 | 0.67 | ENPP2 (0.34) | ENPP2IRAK4 | |
| SCHEMBL2224149 | 0.65 | BRD4 (0.35) | KDRFGFR3ALKBH1FGFR2FGFR4 | |
| SCHEMBL2221611 | 0.65 | BRD4 (0.36) | ENPP2KDRFGFR3ALKBH1BRD4 | |
| SCHEMBL13449340 | 0.64 | BRD4 (0.34) | KDRFGFR3ALKBH1BRD4CCL2 | |
| SCHEMBL164227 | 0.64 | BRD4 (0.37) | ENPP2KDRFGFR3FGFR2BRD4 | |
| SCHEMBL173429 | 0.64 | BRD4 (0.34) | ENPP2BRD4CCL2IRAK4 | |
| SCHEMBL2709532 | 0.64 | NPC1 (0.54) | RXRARXRBSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084402-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-14 | — | — | WO | disclosed |