Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | ACACA | Q13085 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249872 | 0.97 | ACLY (0.56) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL27513732 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL4303064 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL22396506 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL6521284 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| Calcium SCHEMBL30004003 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL4540511 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| Hydrochloric Acid SCHEMBL5669467 | 0.95 | ACLY (0.54) | ACLYACACBACACAPPARATBXAS1 | |
| Formaldehyde SCHEMBL2219271 | 0.93 | ACLY (0.48) | ACLYACACBACACAPPARATBXAS1 | |
| SCHEMBL10445069 | 0.91 | ACLY (0.50) | ACLYACACBACACAPPARATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084850-A1 | PRODRUGS FOR THE TREATMENT OF SCHIZOPHRENIA AND BIPOLAR DISEASE | ALKERMES, INC. (US) | 2011-07-14 | — | — | WO | disclosed |