Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 7/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345961 | 0.82 | MCHR1 (0.33) | HCRTR1HCRTR2HDAC1HDAC8HDAC6 | |
| SCHEMBL2221964 | 0.78 | HDAC6 (0.41) | HDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2221954 | 0.78 | HDAC1 (0.33) | HCRTR1HCRTR2HDAC1HDAC8HDAC6 | |
| SCHEMBL2221125 | 0.74 | HDAC4 (0.38) | HDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL6976073 | 0.73 | HDAC8 (0.36) | HDAC1HDAC8HDAC6PDE4BLMNA | |
| SCHEMBL14297246 | 0.73 | MCHR1 (0.34) | HDAC1HDAC8HDAC6PPARGPPARA | |
| SCHEMBL12517334 | 0.70 | HDAC4 (0.39) | HDAC1HDAC8HDAC6HDAC4 | |
| SCHEMBL2224057 | 0.68 | HDAC4 (0.46) | HDAC1HDAC8HDAC6PPARGPPARA | |
| SCHEMBL2223308 | 0.67 | HDAC4 (0.43) | HDAC1HDAC8HDAC6PPARGPPARA | |
| SCHEMBL14752482 | 0.67 | MCHR1 (0.40) | HDAC1HDAC8HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |