Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2222370 | 0.83 | HDAC6 (0.36) | HDAC6HDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL2221115 | 0.78 | HCRTR1 (0.32) | HDAC6HDAC4HDAC1HDAC8 | |
| SCHEMBL14297329 | 0.75 | HPGD (0.35) | HDAC6HDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL2223818 | 0.74 | HDAC1 (0.35) | HDAC6HDAC4HDAC1HDAC3HDAC8 | |
| SCHEMBL6976073 | 0.72 | HDAC8 (0.36) | HDAC6HDAC1HDAC8 | |
| SCHEMBL2270409 | 0.71 | HDAC6 (0.45) | HDAC6HDAC4HDAC1HDAC3HDAC8 | |
| SCHEMBL2277976 | 0.69 | HDAC6 (0.41) | HDAC6HDAC4HDAC1HDAC3 | |
| SCHEMBL2221120 | 0.67 | HDAC6 (0.41) | HDAC6HDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL2223073 | 0.66 | HDAC6 (0.40) | HDAC6HDAC4HDAC1HDAC3HDAC7 | |
| SCHEMBL2221125 | 0.66 | HDAC4 (0.38) | HDAC6HDAC4HDAC1HDAC7HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523560-A1 | COMPOUNDS AND METHODS | Tempero Pharmaceuticals, Inc. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011088187-A1 | COMPOUNDS AND METHODS | TEMPERO PHARMACEUTICALS, INC. (US) | 2011-07-21 | — | — | WO | disclosed |