⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroform SCHEMBL10949561 | 0.89 | LMNA (1.00) | — | |
| Chloroform SCHEMBL30536988 | 0.89 | — | — | |
| Chloroform SCHEMBL10950487 | 0.89 | LMNA (1.00) | — | |
| Chloroform SCHEMBL88 | 0.89 | — | — | |
| Chloroform SCHEMBL11043408 | 0.89 | LMNA (1.00) | — | |
| Chloroform SCHEMBL2084455 | 0.89 | — | — | |
| Chloroform SCHEMBL381845 | 0.80 | — | — | |
| Chloroform SCHEMBL3072564 | 0.80 | — | — | |
| Chloroform SCHEMBL10869283 | 0.80 | — | — | |
| Chloroform SCHEMBL21830375 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10112958-B2 | N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-YL)-1,3-thiazol-4-YL] amides | PFIZER INC. (US) | 2018-10-30 | — | — | US | disclosed |
| EP-3353183-A1 | N-[2-(2-AMINO-6,6-DISUBSTITUTED-4, 4A, 5, 6-TETRAHYDROPYRANO [3,4-D][1,3]THIAZIN-8A (8H)-YL) -1, 3-THIAZOL-4-YL]AMIDES | Pfizer Inc (US) | 2018-08-01 | — | — | EP | disclosed |
| US-20170305931-A1 | N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES | PFIZER INC. (US) | 2017-10-26 | — | — | US | disclosed |
| US-9751895-B2 | N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides | PFIZER INC. (US) | 2017-09-05 | — | — | US | disclosed |
| US-20170088558-A1 | N-[2-(2-Amino-6,6-Disubstituted-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-YL)-1,3-Thiazol-4-YL]Amides | PFIZER INC. (US) | 2017-03-30 | — | — | US | disclosed |
| WO-2017051276-A1 | N-[2-(2-AMINO-6,6-DISUBSTITUTED-4, 4A, 5, 6-TETRAHYDROPYRANO [3,4-D][1,3] THIAZIN-8A (8H)-YL) -1, 3-THIAZOL-4-YL] AMIDES | PFIZER INC. (US) | 2017-03-30 | — | — | WO | disclosed |
| US-8501036-B2 | Silica gel compositions containing alkali metals and alkali metal alloys | SIGNA CHEMISTRY, INC. (US) | 2013-08-06 | — | — | US | disclosed |
| US-8431529-B2 | Bi-dentate compounds as kinase inhibitors | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-04-30 | — | — | US | disclosed |
| EP-2522422-A2 | Silica gel compositions containing alkali metals and alkali metal alloys | Lefenfeld, Michael (US) | 2012-11-14 | — | — | EP | disclosed |
| EP-2520364-A2 | Silica gel compositions containing alkali metals and alkali metal alloys | Lefenfeld, Michael (US) | 2012-11-07 | — | — | EP | disclosed |
| US-8007762-B2 | Silica gel compositions containing alkali metals and alkali metal alloys | SIGNA CHEMISTRY, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| US-20110172164-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-07-14 | — | — | US | disclosed |
| US-20100166648-A1 | SILICA GEL COMPOSITIONS CONTAINING ALKALI METALS AND ALKALI METAL ALLOYS | SIGNA CHEMISTRY, INC. (US) | 2010-07-01 | — | — | US | disclosed |
| US-7709410-B2 | sodium or potassium or alloy absorbed into silica gel pores; reacts with dry oxygen; improved handling characteristics and retain the reactivity of the neutral alkali metal or alloy; can be used as reducing agent | SIGNA CHEMISTRY, INC. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090041614-A1 | sodium or potassium or alloy absorbed into silica gel pores; reacts with dry oxygen; improved handling characteristics and retain the reactivity of the neutral alkali metal or alloy; can be used as reducing agent | SIGNA CHEMISTRY, INC. | 2009-02-12 | — | — | US | disclosed |
| US-7410567-B2 | Prepared by mixing a liquid Group 1 metal with porous silica gel in an inert atmosphere under isothermal conditions to absorb the metal into the silica gel pores; used as a reduction catalyst in dehalogenation, desulfurization, Wurtz, and Birch reactions; contacting organic compound with metal/silica gel | SIGNA CHEMISTRY, LLC (US) | 2008-08-12 | — | — | US | disclosed |
| US-20070167317-A1 | Prepared by mixing a liquid Group 1 metal with porous silica gel in an inert atmosphere under isothermal conditions to absorb the metal into the silica gel pores; used as a reduction catalyst in dehalogenation, desulfurization, Wurtz, and Birch reactions; contacting organic compound with metal/silica gel | SIGNA CHEMISTRY, LLC (US) | 2007-07-19 | — | — | US | disclosed |
| US-7211539-B2 | Prepared by mixing a liquid Group 1 metal with porous silica gel in an inert atmosphere under isothermal conditions to absorb the metal into the silica gel pores | SIGNA CHEMISTRY, LLC (US) | 2007-05-01 | — | — | US | disclosed |
| CN-1906140-A | Silica gel compositions comprising alkali metals and alkali metal alloys | LEFENFELD MICHAEL (US) | 2007-01-31 | — | — | CN | disclosed |
| US-20050151278-A1 | Prepared by mixing a liquid Group 1 metal with porous silica gel in an inert atmosphere under isothermal conditions to absorb the metal into the silica gel pores; used as a reduction catalyst in dehalogenation, desulfurization, Wurtz, and Birch reactions | SIGNA CHEMISTRY, INC. | 2005-07-14 | — | — | US | disclosed |