Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 8/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.55 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | DNPH1 | O43598 | 1/20 | 0.46 |
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21450235 | 0.89 | NT5E (0.54) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL22215137 | 0.87 | CDK1 (0.57) | CDK1CDK2NT5ENPC1CDK5 | |
| SCHEMBL27430176 | 0.85 | CDK1 (0.63) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL19370351 | 0.85 | NT5E (0.50) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL22843545 | 0.82 | CDK1 (0.54) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL19370287 | 0.82 | CCNB2 (0.47) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL20008058 | 0.81 | CDK1 (0.55) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL19370337 | 0.79 | CDK2 (0.45) | CDK1CCNB2CCNB1CCNB3CDK2 | |
| SCHEMBL19370191 | 0.78 | NT5E (0.57) | CDK1CDK2NT5ENPC1CDK5 | |
| SCHEMBL22843495 | 0.78 | CDK2 (0.49) | CDK1CCNB2CCNB1CCNB3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11058704-B2 | Inhibitors of adenosine 5′-nucleotidase | ARCUS BIOSCIENCES, INC. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200222441-A1 | INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE | ARCUS BIOSCIENCES, INC. | 2020-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11058704-B2 | Inhibitors of adenosine 5′-nucleotidase | ENTPD5, NT5C2, ENTPD1 | CDK1 2231/4885CCNB2 4453/4885CCNB1 4347/4885 |
| US-20200222441-A1 | INHIBITORS OF ADENOSINE 5'-NUCLEOTIDASE | ENTPD5, NT5C2, ENTPD1 | CDK1 2246/4885CCNB2 4456/4885CCNB1 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.