Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 12/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 9/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.55 |
| ▸ | CDK2 | P24941 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 3/20 | 0.42 |
| ▸ | CCNH | P51946 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27430176 | 0.85 | CDK1 (0.63) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL23080226 | 0.82 | CDK1 (0.54) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL22214990 | 0.81 | CDK1 (0.55) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL23080210 | 0.80 | NAE1 (0.54) | CSNK1A1 | |
| SCHEMBL23080231 | 0.80 | NAE1 (0.54) | CSNK1A1 | |
| SCHEMBL23080272 | 0.80 | CDK1 (0.53) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL23080242 | 0.80 | CCNB2 (0.48) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL21450235 | 0.79 | NT5E (0.54) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL25566842 | 0.77 | ADORA2A (0.54) | CDK1CCNB1CCNB2CCNB3CDK2 | |
| SCHEMBL23080206 | 0.76 | SLC29A1 (0.46) | CDK1CCNB1CCNB2CCNB3HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-03-11 | — | — | US | disclosed |
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | CDK1 14/4885CCNB1 95/4885CCNB2 238/4885 |
| US-20210070798-A1 | Inhibitors of E1 activating enzymes | ECE1, RNASE1, RCE1 | CDK1 4/4885CCNB1 189/4885CCNB2 485/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.