SCHEMBL222161

SCHEMBL222161

C[C@@H]1CC[C@H](C(O)C(F)(F)F)N1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 1/20 0.32
TSHR P16473 1/20 0.32
CYP2C19 P33261 1/20 0.32
TDP1 Q9NUW8 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11963359 1.00 CYP2C9 (0.32) CYP2C9TSHRCYP2C19TDP1
SCHEMBL20354560 0.75
SCHEMBL20444318 0.73
SCHEMBL13677601 0.73
SCHEMBL13677600 0.73
SCHEMBL21278247 0.71
SCHEMBL12892128 0.70 CYP2C9 (0.35) CYP2C9TSHRCYP2C19TDP1
SCHEMBL2757138 0.67
SCHEMBL21169203 0.65
SCHEMBL19034907 0.64 DPP4 (0.30) CYP2C9TSHRCYP2C19TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 US disclosed
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2020-11-19 US disclosed
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2020-08-04 US disclosed
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2019-02-07 US disclosed
US-10106500-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2018-10-23 US disclosed
US-20170247325-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2017-08-31 US disclosed
US-9675583-B2 Selective androgen receptor modulators (SARMS) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2017-06-13 US disclosed
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2016-02-11 US disclosed
US-9139520-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2015-09-22 US disclosed
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-11-27 US disclosed
US-8748633-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2014-06-10 US disclosed
US-20130184206-A1 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-07-18 US disclosed
EP-2222636-B1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARM INC (US) 2013-04-10 EP disclosed
US-8354446-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2013-01-15 US disclosed
EP-2489656-A1 Selective androgen receptor modulators (sarms) and uses thereof Ligand Pharmaceuticals Inc. (US) 2012-08-22 EP disclosed
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2012-01-05 US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US disclosed
EP-2222636-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF Ligand Pharmaceuticals Inc. (US) 2010-09-01 EP disclosed
WO-2009082437-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2010-08-12 WO disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130184206-A1 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1557/4885TSHR 765/4885CYP2C19 1502/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG CYP2C9 1076/4885TSHR 606/4885CYP2C19 1021/4885
US-20170247325-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-10106500-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG CYP2C9 1076/4885TSHR 606/4885CYP2C19 1021/4885
US-20160038461-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-20190040006-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-20140350065-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1958/4885TSHR 763/4885CYP2C19 1991/4885
US-10730831-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG CYP2C9 1076/4885TSHR 606/4885CYP2C19 1021/4885
US-20120004220-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG CYP2C9 1557/4885TSHR 765/4885CYP2C19 1502/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.