Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.40 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TYR | P14679 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14032753 | 0.72 | HMGCR (0.40) | ALOX5HMGCRTYRHIF1AALDH1A1 | |
| SCHEMBL27887691 | 0.70 | HMGCR (0.45) | ALOX5HMGCRALOX15KDM4EALDH1A1 | |
| SCHEMBL27558788 | 0.70 | HIF1A (0.45) | ALOX5HMGCRALOX15HIF1AALDH1A1 | |
| SCHEMBL16736576 | 0.69 | HMGCR (0.50) | ALOX5HMGCRALOX15TYRHIF1A | |
| SCHEMBL15107550 | 0.69 | HMGCR (0.46) | ALOX5HMGCRHIF1ALMNAMAPT | |
| SCHEMBL27440129 | 0.69 | HPGD (0.43) | ALOX5HMGCRALOX15HIF1AKDM4E | |
| SCHEMBL12107903 | 0.69 | HMGCR (0.41) | ALOX5HMGCRALOX15TYRHIF1A | |
| SCHEMBL16736920 | 0.69 | HMGCR (0.53) | ALOX5HMGCRALOX15TYRHIF1A | |
| SCHEMBL27679370 | 0.68 | ALOX5 (0.40) | ALOX5HMGCRALOX15HIF1AKDM4E | |
| SCHEMBL11374001 | 0.68 | HMGCR (0.42) | ALOX5HMGCRTYRHIF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146682-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-07-16 | — | — | WO | disclosed |