Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IAPP | P10997 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.40 |
| ▸ | GABRD | O14764 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.40 |
| ▸ | GABRE | P78334 | 2/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825226 | 0.81 | MAPK1 (0.53) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL9318646 | 0.76 | MAPK1 (0.49) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL30111868 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL30031450 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL29878684 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL22978646 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL31161438 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL23714349 | 0.75 | MAPK1 (0.47) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL12488360 | 0.75 | MAPK1 (0.51) | MAPK1MAPTLCKALDH1A1KDM4E | |
| SCHEMBL30100067 | 0.75 | MAPK1 (0.51) | MAPK1MAPTLCKALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146682-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-07-16 | — | — | WO | disclosed |