Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.48 |
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18825226 | 0.86 | MAPK1 (0.53) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL10467645 | 0.85 | MAPK1 (0.52) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9641326 | 0.83 | ATM (0.42) | MAPK1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL17490653 | 0.83 | KDM4E (0.44) | MAPK1KDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL23714349 | 0.80 | MAPK1 (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL9318957 | 0.80 | KDM4E (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL21713467 | 0.80 | L3MBTL1 (0.40) | MAPK1KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL22978646 | 0.80 | MAPK1 (0.47) | MAPK1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17029063 | 0.80 | GABRP (0.51) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL12488360 | 0.80 | MAPK1 (0.51) | MAPK1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281943-B1 | Substituted pyridine-2,4-carboxylic acid derivatives, process for their preparation, their use as well as medicaments based on these compounds | HOECHST AG (DE) | 1994-01-12 | — | — | EP | claimed |
| US-12492187-B2 | Factor XI activation inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-12-09 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-05-11 | — | — | US | disclosed |
| EP-4125892-A1 | FACTOR XI ACTIVATION INHIBITORS | Merck Sharp & Dohme LLC (US) | 2023-02-08 | — | — | EP | disclosed |
| WO-2021202254-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-07 | — | — | WO | disclosed |
| WO-2021202254-A1 | FACTOR XI ACTIVATION INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2021-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492187-B2 | Factor XI activation inhibitors | F11, TFPI, F13B | MAPK1 1441/4885GABRA1 3338/4885GABRG2 3119/4885 |
| US-20230147170-A1 | FACTOR XI ACTIVATION INHIBITORS | F11, TFPI, F13B | MAPK1 1441/4885GABRA1 3338/4885GABRG2 3119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.