SCHEMBL2221990

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2222628	0.90	MAPT (0.54)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL2221835	0.90	MAPT (0.53)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL2224197	0.90	MAPT (0.62)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL14632680	0.89	MAPT (0.51)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL2221551	0.88	MAPT (0.66)	MAPTL3MBTL1KDM4EPOLBNPSR1
	SCHEMBL2222557	0.87	MAPT (0.59)	MAPTSMN1; SMN2L3MBTL1KDM4EPOLB
	SCHEMBL12517212	0.87	MAPT (0.59)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL12517207	0.87	MAPT (0.59)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E
	SCHEMBL2353100	0.87	MAPT (0.59)	MAPTL3MBTL1KDM4EPOLBNPSR1
	SCHEMBL2221133	0.86	MAPT (0.56)	MAPTSMN1; SMN2MAPK1L3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.