Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | CNR2 | P34972 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24589220 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2HPGDHTTEPHX2KDM4E | |
| SCHEMBL24228172 | 0.84 | SMN1; SMN2 (0.35) | SMN1; SMN2HPGDHTTHDAC3HDAC4 | |
| SCHEMBL24435629 | 0.81 | SMN1; SMN2 (0.38) | SMN1; SMN2HPGDHTTKDM4EHDAC3 | |
| SCHEMBL22223342 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHTTEPHX2KDM4E | |
| SCHEMBL22223343 | 0.76 | SMN1; SMN2 (0.44) | SMN1; SMN2HPGDHTTEPHX2KDM4E | |
| SCHEMBL23179896 | 0.74 | SIGMAR1 (0.36) | SMN1; SMN2HPGDHTTFAAHMEN1 | |
| SCHEMBL22688034 | 0.71 | PAOX (0.33) | — | |
| SCHEMBL24588450 | 0.71 | HDAC3 (0.46) | SMN1; SMN2HPGDHTTEPHX2KDM4E | |
| SCHEMBL24589222 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTEPHX2KDM4E | |
| SCHEMBL24588472 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2HPGDHTTEPHX2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146521-A2 | RNAI AGENTS FOR INHIBITING EXPRESSION OF HIF-2 ALPHA (EPAS1), COMPOSITIONS THEREOF, AND METHODS OF USE | Arrowhead Pharmaceuticals, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |