Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 6/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24588972 | 0.89 | PTGS1 (0.42) | PTGS1PTGS2FOLH1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22223319 | 0.86 | PTGS1 (0.48) | PTGS1PTGS2FOLH1SMN1; SMN2ALDH1A1 | |
| SCHEMBL24589085 | 0.85 | LPAR2 (0.39) | PTGS1PTGS2LPAR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL22223321 | 0.84 | PTGS1 (0.61) | PTGS1PTGS2FOLH1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22044572 | 0.82 | PTGS1 (0.45) | PTGS1PTGS2FOLH1SMN1; SMN2ALDH1A1 | |
| SCHEMBL22223438 | 0.82 | FOLH1 (0.40) | LPAR2FOLH1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL22223388 | 0.82 | LPAR2 (0.48) | PTGS1PTGS2LPAR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL24589088 | 0.81 | FOLH1 (0.39) | LPAR2FOLH1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL24589068 | 0.81 | FOLH1 (0.39) | LPAR2FOLH1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL12946729 | 0.79 | NOD1 (0.49) | PTGS1PTGS2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220204976-A1 | RNAi Agents for Inhibiting Expression of HIF-2 alpha (EPAS1), Compositions Thereof, and Methods of Use | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2022-06-30 | — | — | US | disclosed |
| WO-2020146521-A2 | RNAI AGENTS FOR INHIBITING EXPRESSION OF HIF-2 ALPHA (EPAS1), COMPOSITIONS THEREOF, AND METHODS OF USE | Arrowhead Pharmaceuticals, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220204976-A1 | RNAi Agents for Inhibiting Expression of HIF-2 alpha (EPAS1), Compositions Thereof, and Methods of Use | EPAS1, HIF1AN, HIF1A | PTGS1 1489/4885PTGS2 607/4885LPAR2 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.