Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.42 |
| ▸ | FOLH1 | Q04609 | 4/20 | 0.41 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22223371 | 0.96 | TLR2 (0.46) | NOD1FOLH1SLC6A5TLR2CYP19A1 | |
| SCHEMBL24588464 | 0.88 | NOD1 (0.40) | NOD1FOLH1SLC6A5TLR2CYP19A1 | |
| SCHEMBL25919998 | 0.84 | GLP1R (0.47) | NOD1FOLH1TLR2EPHX2 | |
| SCHEMBL20651093 | 0.81 | HDAC1 (0.38) | FOLH1CYP19A1EPHX2 | |
| SCHEMBL25973097 | 0.81 | HDAC1 (0.38) | FOLH1CYP19A1EPHX2 | |
| SCHEMBL21892048 | 0.80 | SMN1; SMN2 (0.49) | CYP19A1EPHX2MEN1FAAHKMT2A | |
| SCHEMBL18704703 | 0.80 | SMN1; SMN2 (0.49) | CYP19A1EPHX2MEN1FAAHKMT2A | |
| SCHEMBL25920623 | 0.79 | TLR2 (0.37) | NOD1FOLH1TLR2EPHX2 | |
| SCHEMBL19703810 | 0.79 | HPGD (0.48) | SLC6A5CYP19A1EPHX2FAAHDNM1 | |
| SCHEMBL19704265 | 0.79 | HPGD (0.48) | SLC6A5CYP19A1EPHX2FAAHDNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020146521-A2 | RNAI AGENTS FOR INHIBITING EXPRESSION OF HIF-2 ALPHA (EPAS1), COMPOSITIONS THEREOF, AND METHODS OF USE | Arrowhead Pharmaceuticals, Inc. (US) | 2020-07-16 | — | — | WO | disclosed |