Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL171272 | 0.70 | HAVCR2 (0.48) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL2756447 | 0.70 | — | — | |
| SCHEMBL10281378 | 0.68 | HAVCR2 (0.47) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL17128162 | 0.68 | HAVCR2 (0.47) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL1916539 | 0.67 | HAVCR2 (0.37) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL19153783 | 0.65 | HAVCR2 (0.33) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL6290064 | 0.65 | PDCD1 (0.47) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL12735615 | 0.64 | WNT3A (0.38) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL12082584 | 0.64 | HRH4 (0.41) | HAVCR2PARP1PARP15PARP3 | |
| SCHEMBL19152668 | 0.64 | PARP1 (0.39) | HAVCR2PARP1PARP15PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523957-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. Hoffmann-La Roche AG (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011086053-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2011-07-21 | — | — | WO | disclosed |