Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22227202 | 0.91 | USP30 (0.42) | GRM5USP30CRBNPIK3CDPIK3CA | |
| SCHEMBL22226579 | 0.88 | HPGD (0.43) | GRM5USP30POLBKMT2A | |
| SCHEMBL24100933 | 0.88 | GRM5 (0.42) | GRM5USP30CRBNPIK3CDPIK3CA | |
| SCHEMBL24099642 | 0.87 | SMN1; SMN2 (0.42) | GRM5USP30PIK3CARAB9AMAPT | |
| SCHEMBL24100527 | 0.87 | HPGD (0.45) | GRM5USP30POLBKMT2A | |
| SCHEMBL24101118 | 0.86 | HPGD (0.47) | GRM5USP30PIK3CAKMT2A | |
| SCHEMBL24100515 | 0.86 | GRM5 (0.41) | GRM5USP30CRBNPIK3CDPIK3CA | |
| SCHEMBL22226872 | 0.85 | USP30 (0.38) | GRM5USP30CRBNPIK3CDPIK3CA | |
| SCHEMBL24100386 | 0.85 | USP30 (0.38) | GRM5USP30CRBNPIK3CAVNN1 | |
| SCHEMBL22227266 | 0.84 | HPGD (0.45) | GRM5USP30CRBNPIK3CAVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |