Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 3/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22226923 | 0.92 | NNMT (0.63) | NNMTCYP2C9CYP2C19JAK2PLK4 | |
| SCHEMBL22226925 | 0.91 | NNMT (0.58) | NNMTCYP2C9CYP2C19CA12CA1 | |
| SCHEMBL13332908 | 0.84 | NNMT (0.66) | NNMTPIK3C3MAPK1ALDH1A1KMT2A | |
| SCHEMBL22226927 | 0.83 | NNMT (0.43) | NNMTCYP2C9CYP2C19CA12CA1 | |
| SCHEMBL22225994 | 0.80 | GRM5 (0.45) | NNMTCYP2C9CYP2C19MAPK1ALDH1A1 | |
| SCHEMBL25345966 | 0.78 | CYP2C9 (0.43) | CYP2C9CYP2C19CA12CA1CA2 | |
| SCHEMBL30527021 | 0.78 | CYP2C9 (0.43) | CYP2C9CYP2C19CA12CA1CA2 | |
| SCHEMBL31396199 | 0.78 | CYP2C9 (0.46) | NNMTCYP2C9CYP2C19JAK2PLK4 | |
| SCHEMBL25345052 | 0.77 | CYP2C9 (0.43) | CYP2C9CYP2C19CA12CA1CA2 | |
| Hydrochloric Acid SCHEMBL25345056 | 0.77 | CYP2C9 (0.43) | CYP2C9CYP2C19CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |
| WO-2020145250-A1 | 15-PGDH INHIBITOR | 杏林製薬株式会社 | 2020-07-16 | — | — | WO | disclosed |