Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928178 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL16765451 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL928176 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL16765024 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL6345280 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL6355372 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL6347477 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL8270269 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL16765034 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD | |
| SCHEMBL16765693 | 1.00 | GPR119 (0.48) | GPR119ALDH1A1KDM4EPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109305959-B | Pyrimidinyl tyrosine kinase inhibitors | 比奥根MA公司 | 2022-02-08 | — | — | CN | disclosed |
| CN-113549055-A | Pyrimidinyl tyrosine kinase inhibitors | 比奥根MA公司 | 2021-10-26 | — | — | CN | disclosed |
| EP-3385263-B1 | PYRIMIDINYL TYROSINE KINASE INHIBITORS | BIOGEN MA INC (US) | 2020-07-22 | — | — | EP | disclosed |