Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759793 | 0.91 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL19759581 | 0.90 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL19759593 | 0.88 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL19759697 | 0.85 | ROCK2 (0.57) | ROCK2 | |
| SCHEMBL19759684 | 0.83 | ROCK2 (0.70) | ROCK2 | |
| SCHEMBL19759775 | 0.82 | ROCK2 (0.74) | ROCK2 | |
| SCHEMBL19759689 | 0.82 | ROCK2 (0.67) | ROCK2 | |
| SCHEMBL19759725 | 0.81 | ROCK2 (0.51) | ROCK2 | |
| SCHEMBL19759586 | 0.81 | ROCK2 (0.66) | ROCK2 | |
| SCHEMBL19759591 | 0.80 | ROCK2 (0.51) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3242873-B1 | CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-07-22 | — | — | EP | disclosed |