Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.57 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | GRK2 | P25098 | 2/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.48 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | GRK5 | P34947 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 1/20 | 0.48 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.48 |
| ▸ | GRK7 | Q8WTQ7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759717 | 0.89 | ROCK2 (0.54) | ROCK2AURKAGRK2ROCK1RPS6KA1 | |
| SCHEMBL19759593 | 0.89 | ROCK2 (0.59) | ROCK2AURKAGRK2ROCK1RPS6KA1 | |
| SCHEMBL19759581 | 0.88 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL19759579 | 0.84 | ROCK2 (0.55) | ROCK2GRK2ROCK1 | |
| SCHEMBL19759774 | 0.84 | ROCK2 (0.73) | ROCK2 | |
| SCHEMBL19759687 | 0.83 | AURKA (0.58) | ROCK2AURKAGRK2ROCK1RPS6KA1 | |
| SCHEMBL19759590 | 0.82 | ROCK2 (0.53) | ROCK2GRK2ROCK1 | |
| SCHEMBL19759746 | 0.81 | ROCK2 (0.58) | ROCK2GRK2ROCK1 | |
| SCHEMBL19759691 | 0.81 | ROCK2 (0.73) | ROCK2ROCK1 | |
| SCHEMBL19759588 | 0.80 | ROCK2 (0.63) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3242873-B1 | CYCLIC UREAS AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2020-07-22 | — | — | EP | disclosed |