Sugi Predict

Sugi Predict / Compounds / SCHEMBL22228781

SCHEMBL22228781

SCHEMBL22228781

CS(=O)(=O)NC1CCC(Nc2ncc(F)c(-c3cnc4ccccn34)n2)CC1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK8 P45983 9/20 0.70
▸ MAPK9 P45984 7/20 0.70
▸ CDK2 P24941 7/20 0.51
▸ JUN P05412 2/20 0.51
▸ IGF1R P08069 3/20 0.48
▸ IRAK4 Q9NWZ3 4/20 0.47
▸ CCNT1 O60563 1/20 0.45
▸ FLT3 P36888 1/20 0.45
▸ CDK9 P50750 1/20 0.45
▸ MAPK10 P53779 3/20 0.44
▸ CDK1 P06493 3/20 0.43
▸ CCNB1 P14635 3/20 0.43
▸ CCNE1 P24864 3/20 0.43
▸ CCNB2 O95067 1/20 0.43
▸ CCNE2 O96020 1/20 0.43
▸ CDK5 Q00535 1/20 0.43
▸ CDK5R1 Q15078 1/20 0.43
▸ CCNB3 Q8WWL7 1/20 0.43
▸ CDK4 P11802 2/20 0.42
▸ CCND1 P24385 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31500989 1.00 MAPK8 (0.70) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL22228780 1.00 MAPK8 (0.70) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL22252904 0.88 MAPK9 (0.55) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL22228853 0.88 CDK2 (0.59) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL31500962 0.88 CDK2 (0.59) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL31501018 0.85 CDK9 (0.58) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL31501021 0.85 CDK9 (0.58) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL22228715 0.85 CDK9 (0.58) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL31501022 0.85 CDK9 (0.58) MAPK8MAPK9CDK2JUNIGF1R
SCHEMBL20468460 0.84 CDK2 (0.56) MAPK8MAPK9CDK2JUNIGF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3577116-B1 DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-A]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS CHANGZHOU QIANHONG BIO PHARMA CO LTD (CN) 2025-04-23 — — EP disclosed
US-11111245-B2 Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents AUCENTRA THERAPEUTICS PTY LTD (AU) 2021-09-07 — — US disclosed
US-20200231586-A1 DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS AUCENTRA THERAPEUTICS PTY LTD (AU) 2020-07-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200231586-A1 DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS CDK2, CDKL1, CDKL2 MAPK8 137/4885MAPK9 182/4885CDK2 1/4885
US-11111245-B2 Derivatives of N-cycloalkyl/heterocycloalkyl-4-(imidazo[1,2-a]pyridine)pyrimidin-2-amine as therapeutic agents CDK2, CDKL1, CDKL2 MAPK8 137/4885MAPK9 182/4885CDK2 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.